The Seal of UPHSD is a cameo depicting in semi-abstract form the image of Our Mother of Perpetual help clasping in her arms the infant Jesus. This stands for the Christian precepts to which the college adheres and which binds its aspirations and hopes. The infant Jesus is symbolic of the youth who must be nurtured by a devoted and loving Mary which speaks of the motherly care and love of the college.

The branches of laurel leaves signify excellence which the college pursues, not only in academics but also in leadership and in human relations. The branches, symbol of dignity, honor and reward used by the ancients Greeks also stands for the fulfillment of the aspirations of the college as it carries on propagating its mission.

The Cameo is bordered by oval lines of gold set as maroon and white background which are the colors of the institution. Maroon symbolizes the red blood of courage, vigor and determination; white for purity, and gold for generosity, abundance, hope and vision.